HCID 22385845, compound → HCID 86710800, compound

HRID 1400744Notes

Reaction equation

HRID 1400744 reaction equation
C(OCC([O-])=O)(C)(C)C.[CH2:10]([O:13][C:14]1([CH3:54])[CH2:19][CH2:18][N:17]([C:20]2[N:25]3[N:26]=[C:27]([C:29]4[CH:30]=[C:31]([C:35]5[CH:40]=[C:39]([Cl:41])[CH:38]=[CH:37][C:36]=5[OH:42])[CH:32]=[CH:33][CH:34]=4)[CH:28]=[C:24]3[N:23]=[C:22]([CH3:43])[C:21]=2[CH:44]([O:49][C:50]([CH3:53])([CH3:52])[CH3:51])[C:45]([O:47][CH3:48])=[O:46])[CH2:16][CH2:15]1)[CH:11]=[CH2:12]>>[CH2:10]([O:13][C:14]1([CH3:54])[CH2:15][CH2:16][N:17]([C:20]2[N:25]3[N:26]=[C:27]([C:29]4[CH:30]=[C:31]([C:35]5[CH:40]=[C:39]([Cl:41])[CH:38]=[CH:37][C:36]=5[OH:42])[CH:32]=[CH:33][CH:34]=4)[CH:28]=[C:24]3[N:23]=[C:22]([CH3:43])[C:21]=2[C@H:44]([O:49][C:50]([CH3:53])([CH3:52])[CH3:51])[C:45]([O:47][CH3:48])=[O:46])[CH2:18][CH2:19]1)[CH:11]=[CH2:12]

Participants

3

Reactant 2

HCID 22385845HCID 22385845, compoundHCID 123428141HCID 123428141, compound

Product 1

HCID 86710800HCID 86710800, compound

Procedure

(S)-Methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(5′-chloro-2′4(S)-pent-4-en-2-yloxy)-[1,1′-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate: Prepared from S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(5′-chloro-2′-hydroxy-[1,1′-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate using the same procedure as intermediate 169 in 94% yield. LCMS (M+1)=701.35.

Sources & evidence

ORD record
ord-6a4a00f92e1e4c58b9e881d60528c3b3
Source dataset
uspto-grants-2014_12
Patent number
US08906929B2

Reaction notes

Loading…