HCID 89971357, compound → HCID 86578355, compound

Participants

Reaction Steps

Prepared from a 2:1 mixture of (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(5′-fluoro-4′-methyl-2′-((S)-pent-4-en-2-yloxy)-[1,1′-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate and (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(3′-fluoro-2′-methyl-6′-((S)-pent-4-en-2-yloxy)-[1,1′-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate using the same procedures as intermediates 170 and example 81 in 9% yield. 1H NMR (400 MHz, Methanol-d4) δ 8.53 (s, 1H), 7.73 (d, J=7.8 Hz, 1H), 7.37 (t, J=7.7 Hz, 1H), 7.19 (d, J=7.6 Hz, 1H), 6.92-6.82 (m, 2H), 6.78 (s, 1H), 5.54 (s, 1H), 4.62-4.43 (m, 2H), 3.83 (d, J=10.5 Hz, 1H), 3.67-3.58 (m, 1H), 3.38 (d, J=6.8 Hz, 1H), 2.87 (d, J=12.2 Hz, 1H), 2.58 (s, 3H), 2.24 (s, 3H), 1.93-1.84 (m, 3H), 1.78-1.59 (m, 5H), 1.57-1.42 (m, 3H), 1.14 (s, 12H), 1.02 (d, J=5.9 Hz, 3H). LCMS (M+1)=659.6.

Provenance & Evidence