HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 89973651, compound → HCID 123532983, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 89973651 | HCID 89973651 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | (1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)(dichloro)((2-((propan-2-yl)oxy)phenyl)methylidene)ruthenium | HCID 11763533 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 123532983 | HCID 123532983 | — |
Reaction Steps
To a mixture of (2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-5-methyl-2-(5′-methyl-2′-((3-methylpent-4-en-2-yl)oxy)-[1,1′-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (250 mg, 0.353 mmol) and CuI (67.2 mg, 0.353 mmol) in DCE (200 mL) at 70° C. was added (1,3-dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride (22.10 mg, 0.035 mmol) and the resulting mixture was refluxed for 2 h. At this point LCMS indicates completion of reaction. Mixture was then concentrated and used as is in the next step without further purification. LCMS (M+H)=681.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08906929B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-c2f4280ed2b5463d9649f877ee9172dd |
| Source note | uspto-grants-2014_12 |