HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1400774Generated: November 2, 2026
HCID 89971610, compound → HCID 123470660, compound
https://huagongshe.com/reaction/1400774
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 89971610 | HCID 89971610 | — |
| Catalyst | (1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)(dichloro)((2-((propan-2-yl)oxy)phenyl)methylidene)ruthenium | HCID 11763533 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 123470660 | HCID 123470660 | — |
Reaction Steps
To a solution of (2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2′,6-difluoro-6′-((S)-pent-4-en-2-yloxy)-[1,1′-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (100 mg, 0.142 mmol, 1.0 equiv) in DCE (70 mL) was added Hoveyda-Grubbs Catalyst 2nd Generation (8.92 mg, 0.014 mmol, 0.1 equiv) and stirred for 5 h at 90° C. Then, the solvent was evaporated and the residue was used in the next step without further purification. LCMS (M+1)=675.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08906929B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-2cace9cb0b444400adf2b3a218843348 |
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| Source note | uspto-grants-2014_12 |
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