3-Aminobenzamide → HCID 67444082, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 104 (83 mg, 0.191 mmol, scheme 26) in THF (19 mL) at −10° C. was added DIPEA (334 μl, 1.910 mmol) and triphosgene (56.7 mg, 0.191 mmol). The reaction mixture was stirred for 90 min at −10° C. then 3-aminobenzamide (104 mg, 0.764 mmol) was added. The reaction mixture was allowed to warm to RT, stirred for 3 h, quenched with MeOH, and concentrated. The residue was suspended in 2 mL of MeOH and a saturated aqueous solution of ammonium chloride was added, stirred for 30 min, collected by filtration, and dried. The crude product was purified by Biotage (SNAP 25 g cartridge; MeOH/DCM: 0/100 to 30/70 over 20 CV) to produce a material that was further purified by Gilson (Phenomenex, Luna, 15μ, C18(2) 100A, 250×50.00 mm, 15 μm, 0.05% of formic acid in both MeOH/water (30 mL/min): 30/70 to 95/5 over 60 min), to afford the title compound 106 (8.7 mg, 0.015 mmol, 7% yield, formate salt) as an yellow solid. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 11.34 (s, 1H), 11.06 (s, 1H), 8.55-8.50 (m, 2H), 8.41 (s, 4H), 8.35 (s, 1H), 8.26 (d, J=8.0 Hz, 1H), 8.05 (t, J=2.0 Hz, 1H), 7.90-7.77 (m, 3H), 7.71-7.67 (m, 1H), 7.44-7.38 (m, 3H), 7.34-7.27 (m, 2H), 6.68 (dd, J=5.2, 0.8 Hz, 1H), 4.46 (s, 2H), 3.31 (t, J=7.2 Hz, 2H), 2.31 (t, J=8.0 Hz, 2H), 1.95 (quint, J=8.0 Hz, 2H). MS (m/z): 597.5 (M+H).

Provenance & Evidence