Ammonium Chloride → HCID 58474497, compound

Participants

Reaction Steps

To a suspension of 125 (1.5 g, 3.24 mmol) in MeOH (60 mL) was added Zinc powder (1.693 g, 25.9 mmol) and NH4Cl (0.346 g, 6.47 mmol) and the reaction mixture was heated to reflux for 5 hours. The mixture was cooled to RT and filtered. The filtrate was concentrated and the residue was dissolved in DCM and washed with water. The organic phase was collected, dried over anhydrous Na2SO4, filtered and concentrated to give title compound 126 (1.3 g, 93% yield) as a brown oil which became a puffy solid after removal of residual solvent in high vacuum. MS (m/z)=434.50 (M+H)

Provenance & Evidence