Cyclopropylamine → HCID 67443336, compound

Participants

Reaction Steps

To a solution of 136 (77 mg, 0.176 mmol) in THF (10 mL) was added TEA (0.074 mL, 0.528 mmol) and triphosgene (52.2 mg, 1.451 mmol) in THF (5 mL) and the mixture was stirred at RT for an hour. Cyclopropylamine (10.5 mg, 0.176 mmol) was added and the reaction mixture was stirred at RT overnight. The reaction mixture was then concentrated and partitioned between with DCM and saturated NaHCO3 solution. The organic phase was collected, dried over anhydrous Na2SO4, filtered and concentrated. Purification of the residue by column chromatography (10% MeOH in EtOAc) afforded title compound 137 (47 mg, 51% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 8.69 (s, 1H), 8.50 (d, J=5.48 Hz, 1H), 7.89 (s, 1H), 7.70 (m, 1H), 7.35 (t, J=8.99 Hz, 1H), 7.17 (m, 1H), 7.05 (s, 1H), 6.65 (d, J=5.48 Hz, 1H), 6.55 (m, 1H), 4.46 (s, 2H), 3.82 (s, 3H), 3.22 (t, J=6.84 Hz, 2H), 2.52 (m, 1H), 2.27 (t, J=7.82 Hz, 2H), 1.90 (m, 2H), 0.63 (m, 2H), 0.40 (m, 2H). MS (m/z)=521.638 (M+H)

Provenance & Evidence