Sodium borohydride → HCID 58474793, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 146 (3 g, 7.53 mmol) in DCM (100 mL) and MeOH (100 mL) was added NaBH4 (0.57 g, 15.06 mmol) and the reaction mixture was stirred at 0° C. for 20 min. The mixture was quenched with saturated NH4Cl solution then extracted with DCM. The extract was collected, dried over anhydrous Na2SO4, filtered, concentrated and the residue was purified by flash column chromatography (eluent 10% MeOH in EtOAc) to afford title compound 156 (1 g, 36% yield) as white solid. MS (m/z)=371.40 (M+H).

Provenance & Evidence