Ammonium Chloride → HCID 58474674, compound

Participants

Reaction Steps

To a solution of 159 (300 mg, 0.555 mmol) in MeOH (10 mL) was added zinc powder (145 mg, 2.22 mmol) and ammonium chloride (59.4 mg, 1.11 mmol) and the reaction mixture was heated to reflux for 3 hours. The mixture was cooled to RT and filtered. The solvent was evaporated and the residue was extracted with DCM. The extract was dried over anhydrous Na2SO4, filtered and concentrated. The crude title compound 160 (283 mg, 100% yield) was used in the next step with no additional purification. MS (m/z)=511.2 (M+H).

Provenance & Evidence