Ammonium Chloride → HCID 58474785, compound

Participants

Reaction Steps

To a suspension of 164 (0.5 g, 1.07 mmol) in MeOH (20 mL) was added Zinc (0.28 g, 4.28 mmol) and ammonium chloride (0.114 g, 2.139 mmol) and the reaction mixture was heated to reflux for 3 hours. The mixture was cooled to RT and filtered. The filtrate was concentrated and the resultant oil was partitioned between water and DCM. The organic phase was collected, dried over anhydrous Na2SO4, filtered and concentrated. The resultant solid was triturated with Et2O to give title compound 165 (0.468 mg, 100% yield, crude) as a black solid. MS (m/z) 438.4 (M+H).

Provenance & Evidence