7-Chloro-2-(tributylstannyl)thieno[3,2-b]pyridine → 3-((6-(7-Chlorothieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-1,3-oxazinan-2-one

Participants

Reaction Steps

To a solution of 197 (373 mg, 1.376 mmol) in toluene (10 mL) was added the 7-chloro-2-(tributylstannyl)thieno[3,2-b]pyridine 198 (631 mg, 1.376 mmol) and Pd(PPh3)4 (159 mg, 0.138 mmol). The reaction mixture was heated to reflux for 24 hours. The reaction mixture was then cooled to RT and concentrated. The residue was triturated with Et2O to afford the title compound 199 (363 mg, 73% yield) as beige solid. MS: 360 (MH+).

Provenance & Evidence