Pyridine → HCID 67442475, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the amine 343 (0.9 g, 1.69 mmol) in NMP (10 mL) at 0° C. was added pyridine (0.3 ml, 3.71 mmol) followed by the chloroformate (0.3 mL, 2.38 mmol). The mixture was stirred for 40 min at 0° C. then at room temperature for 120 min, quenched by addition of brine/NaHCO3 solution. A precipitate was formed which was collected by filtration and dried. The crude material was purified by flash column chromatography, eluent a 5 to 10% gradient of MeOH (containing 2% ammonia) in DCM, to afford the title compound 356 (0.528 g, 47.9% yield). MS (m/z): 653.6 (M+1)+.

Provenance & Evidence