Methyl 2-(3-oxocyclopentyl)acetate → HCID 86692376, compound

Participants

Role	Name	HCID	Charge
Reactant	Methyl 2-(3-oxocyclopentyl)acetate	HCID 11355614	—
Reactant	(1R,3aS,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl trifluoromethanesulfonate	HCID 71698666	—
Product	HCID 86692376	HCID 86692376	50.1%

Reaction Steps

The title compound was prepared following the procedure described in method 2 for the preparation of intermediate 1, Step 6, using methyl 2-(3-oxocyclopentyl)acetate as the reactant. (50.1% yield). 1H NMR (400 MHz, CHLOROFORM-d) δ 5.66 (q, J=2.1 Hz, 1H), 3.73 (br. s., 3H), 3.29-3.13 (m, 1H), 2.95-2.78 (m, 1H), 2.67-2.57 (m, 2H), 2.49-2.40 (m, 1H), 2.40-2.28 (m, 1H), 1.77-1.63 (m, 1H). 19F NMR (376 MHz, CHLOROFORM-d) δ −73.53 (s, 3F).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08906889B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-4692fe5a38d44872bfa284624632881b
Source note	uspto-grants-2014_12