HuagongsheHuagongshe Chemistry Print Report · For research reference only
Salicylic Acid → Salicyloyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Salicylic Acid | HCID 338 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Deferasirox | HCID 214348 | — |
| Product | Salicyloyl chloride | HCID 74041 | — |
Reaction Steps
WO2010023685 of Matrix describes the process for the preparation of Deferasirox as shown in scheme III. The process comprises the Salicylic acid reacted with thionyl chloride in the presence of solvent to give salicyloyl chloride, which is reacted with salicylamide to give 2-(2-hydroxyphenyl)-benz[1,3]-oxazine-4-one, then it is condensed with 4-hydrazino benzoic acid to give deferasirox.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907083B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-f27fcd2a1118439c9715342f53b8fb1a |
| Source note | uspto-grants-2014_12 |