Clopidogrel Bisulfate → Clopidogrel

Participants

Reaction Conditions

Reaction Steps

Suspension of Clopidogrel hydrogen sulfate (61 gms) was stirred in dichloromethane (360 ml) and subsequently basified with NaHCO3 solution (10%, 600 ml). The mixture was stirred at 25 to 30° C. for about 10 minutes. The layers were separated and the aqueous layer was extracted with dichloromethane (60 ml.) and washed with water (120 ml.). It was then dried over Na2SO4 and the solvent was distilled off on a water bath at a temperature in the range from 50 to 55° C. to obtain Clopidogrel free base (46.0 gms)

Provenance & Evidence