Clopidogrel Bisulfate → Clopidogrel

Participants

Reaction Conditions

Reaction Steps

Suspension of Clopidogrel hydrogen sulfate (660 gms) was stirred in dichloromethane (3900 ml) & subsequently basified with NaHCO3 solution (10%, 6500 ml). The reaction mixture was stirred at 25 to 30° C. for about 10 minutes. The layers were separated and the aqueous layer was extracted with dichloromethane (650 ml.) and washed with water (1300 ml.). It was then dried over Na2SO4 and the solvent was distilled off on a water bath at 50 to 55° C. to obtain Clopidogrel free base (505 gms).

Provenance & Evidence