Clopidogrel bisulfate → Clopidogrel

Participants

Reaction Conditions

Reaction Steps

A suspension of Clopidogrel hydrogen sulfate (330 gms) was stirred in dichloromethane (1950 ml) and subsequently with NaHCO3 solution (10%, 3300 ml). The mixture was stirred at 25 to 30° C. for about 10 minutes. The layers were separated and aqueous layer was extracted with dichloromethane (325 ml.) and washed with water (1300 ml.). It was then dried over Na2SO4 and the solvent was distilled off on a water bath at a temperature in the range from 50 to 55° C. to obtain Clopidogrel free base (250 gms).

Provenance & Evidence