Water → Clopidogrel Bisulfate

Participants

Reaction Conditions

Reaction Steps

Clopidogrel base (10 gms) was dissolved in decan-1-ol (50 mL) with stirring at 25 to 30° C. and water (0.2 ml) was added to it. Concentrated H2SO4 was added at 10-15° C. Solid material precipitated. The mixture was stirred at room temperature, for 24 hrs. It was filtered, washed with methyl tert-butyl ether (30 ml) and dried at temperature in the range from 30 to 35° C. in a drier, to get 7 g of Clopidogrel bisulfate salt as crystals. Subsequent analysis confirmed that the crystals were clopidogrel hydrogen sulfate Form-I.

Provenance & Evidence