Sulfuric Acid → Clopidogrel Bisulfate

Participants

Reaction Conditions

Reaction Steps

Clopidogrel base (10 gms) was dissolved in decan-1-ol (50 mL) with stirring at 25 to 30° C. Dilute H2SO4 was added at 10-15° C. when the solid material precipitated. The reaction mixture was stirred at room temperature, for 24 hrs. Then the mixture was filtered, washed with methyl tert butyl ether (30 ml) and dried at a temperature in the range from 30 to 35° C. in a drier, to get 8 g of Clopidogrel bisulfate salt as crystals. Subsequent analysis confirmed that the crystals were of Clopidogrel hydrogen sulfate Form-I.

Provenance & Evidence