Lithium Hydroxide → HCID 71468591, compound

Participants

Reaction Steps

(E)-tert-butyl 3-(3-(1-isopropyl-2-(3-(2-methoxy-2-oxoethoxy)benzoyl)hydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate (70 mg, 0.13 mmol) was dissolved in THF/H2O (2 ml/1 ml), stirred for 20 min, lithiumhydroxide (10.96 mg, 0.26 mmol) was slowly drop-wise added, and stirred at room temperature for 12 hr. THF was concentrated under reduced pressure, and after titration with 6N HCl at pH=2, the reaction mixture was diluted with EtOAc, washed with water and brine, dried with anhydrous MgSO4 filtered, and concentrated under reduced pressure so that while solid form of (E)-2-(3-(2-(3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)acryloyl)-2-isopropylhydrazinecarbonyl)phenoxy)acetic acid was obtained (68.1 mg, 99%).

Provenance & Evidence