Ethyl 3-hydroxybenzoate → 3-((5-Chloropyridin-2-yl)oxy)benzoic acid

HRID 1401141Notes

Reaction equation

HRID 1401141 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[OH:9][C:10]1[CH:11]=[C:12]([CH:18]=[CH:19][CH:20]=1)[C:13]([O:15]CC)=[O:14]>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([O:9][C:10]2[CH:11]=[C:12]([CH:18]=[CH:19][CH:20]=2)[C:13]([OH:15])=[O:14])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 24522Ethyl 3-hydroxybenzoateHCID 276852,5-Dichloropyridine

Product 1

HCID 613955833-((5-Chloropyridin-2-yl)oxy)benzoic acid

Procedure

Prepared from 2,5-dichloropyridine and ethyl 3-hydroxybenzoate. 1H NMR (400 MHz, DMSO-d5) δ 13.17 (br. s., 1H), 8.22 (d, 1H), 8.00 (dd, 1H), 7.81 (dd, 1H), 7.60-7.64 (m, 1H), 7.58 (t, 1H), 7.43 (dd, 1H), 7.18 (d, 1H).

Sources & evidence

ORD record
ord-f311c922271049babbe0334daa1e95fa
Source dataset
uspto-grants-2014_12
Patent number
US08907096B2

Reaction notes

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