4-Aminoadamantan-1-ol → N-(5-Hydroxy-adamantan-2-yl)-3-(tetrahydro-pyran-4-ylmethoxy)-benzamide

HRID 1401150Notes

Reaction equation

HRID 1401150 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=2)[C:12]([OH:14])=O)[CH2:3][CH2:2]1.[NH2:18][CH:19]1[CH:26]2[CH2:27][C:22]3([OH:29])[CH2:23][CH:24]([CH2:28][CH:20]1[CH2:21]3)[CH2:25]2>>[OH:29][C:22]12[CH2:27][CH:26]3[CH2:25][CH:24]([CH2:28][CH:20]([CH:19]3[NH:18][C:12](=[O:14])[C:11]3[CH:15]=[CH:16][CH:17]=[C:9]([O:8][CH2:7][CH:4]4[CH2:3][CH2:2][O:1][CH2:6][CH2:5]4)[CH:10]=3)[CH2:21]1)[CH2:23]2

Participants

3

Reactant 2

HCID 28574474-Aminoadamantan-1-olHCID 288754893-(Tetrahydro-2H-pyran-4-ylmethoxy)benzoic Acid

Product 1

HCID 25242330N-(5-Hydroxy-adamantan-2-yl)-3-(tetrahydro-pyran-4-ylmethoxy)-benzamide

Procedure

Prepared from 3-(tetrahydro-pyran-4-ylmethoxy)-benzoic acid and 4-amino-1-hydroxyadamantane. LC-MS (m/z): 386 (M+1).

Sources & evidence

ORD record
ord-6a2aeb3653f841c78b0a002af292f981
Source dataset
uspto-grants-2014_12
Patent number
US08907096B2

Reaction notes

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