4-Aminoadamantan-1-ol → N-(5-Hydroxy-adamantan-2-yl)-3-[2-(tetrahydro-pyran-4-yl)-ethoxy]-benzamide

HRID 1401151Notes

Reaction equation

HRID 1401151 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=2)[C:13]([OH:15])=O)[CH2:3][CH2:2]1.[NH2:19][CH:20]1[CH:27]2[CH2:28][C:23]3([OH:30])[CH2:24][CH:25]([CH2:29][CH:21]1[CH2:22]3)[CH2:26]2>>[OH:30][C:23]12[CH2:28][CH:27]3[CH2:26][CH:25]([CH2:29][CH:21]([CH:20]3[NH:19][C:13](=[O:15])[C:12]3[CH:16]=[CH:17][CH:18]=[C:10]([O:9][CH2:8][CH2:7][CH:4]4[CH2:3][CH2:2][O:1][CH2:6][CH2:5]4)[CH:11]=3)[CH2:22]1)[CH2:24]2

Participants

3

Reactant 2

HCID 28574474-Aminoadamantan-1-olHCID 583476373-(Tetrahydro-pyran-4-ylethoxy)-benzoic acid

Product 1

HCID 25242331N-(5-Hydroxy-adamantan-2-yl)-3-[2-(tetrahydro-pyran-4-yl)-ethoxy]-benzamide

Procedure

Prepared from 3-(tetrahydro-pyran-4-ylethoxy)-benzoic acid and 4-amino-1-hydroxyadamantane. LC-MS (m/z): 400 (M).

Sources & evidence

ORD record
ord-9f1fcdb2b1554431aacd60a61b15fbb2
Source dataset
uspto-grants-2014_12
Patent number
US08907096B2

Reaction notes

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