Sodium Carbonate → HCID 67407904, compound

HRID 1401255Notes

Reaction equation

[OH:1][CH2:2][C@H:3]1[C@H:7]([C:8]2[C:9]([O:30]C)=[CH:10][C:11]([O:28]C)=[C:12]3[C:17]=2[O:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-:26])=[O:25])[CH:19]=2)=[CH:14][C:13]3=[O:27])[CH2:6][CH2:5][N:4]1[CH3:32].Cl.N1C=CC=CC=1.C([O-])([O-])=O.[Na+].[Na+]>CO>[OH:28][C:11]1[CH:10]=[C:9]([OH:30])[C:8]([C@@H:7]2[CH2:6][CH2:5][N:4]([CH3:32])[C@H:3]2[CH2:2][OH:1])=[C:17]2[C:12]=1[C:13](=[O:27])[CH:14]=[C:15]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-:26])=[O:25])[CH:19]=1)[O:16]2

Participants

Conditions

Temperature: 180 °C

Procedure

A mixture of compound of example 24 (0.5 g, 1.13 mmol) and pyridine hydrochloride (1.2 g, 10.38 mmol) was heated at 180° C. for a period of 2.5 hours. The reaction mixture was diluted with methanol (60 mL) and basified with solid Na2CO3 to pH 10. The reaction mixture was filtered, and washed with methanol. The organic layer was concentrated and the residue purified by column chromatography using 0.01% ammonia and 4.5% methanol in chloroform as eluent to afford the title compound.

Workup

filtrationThe reaction mixture was filtered
washwashed with methanol
concentrationThe organic layer was concentrated
customthe residue purified by column chromatography

Sources & evidence

ORD record: ord-ddcbc21130f24dda9cb65498da72d0ce
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08906953B2

Reaction notes

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