Methyl iodide → HCID 178481990, compound

HRID 1401360Notes

Reaction equation

HRID 1401360 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:19][CH3:20]>>[I-:19].[CH2:1]([N:8]1[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N+:10]([CH3:20])=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6328Methyl iodide2×HCID 113108941-Benzyl-4-phenyl-1,2,3-triazole

Product 1

HCID 178481990HCID 178481990, compound

Conditions

Temperature
40 °C

Procedure

1-benzyl-4-phenyl-1H-1,2,3-triazole (0.52 g, 2.197 mmol) prepared above and iodomethane (2 ml, 32.0 mmol) were added to a 20 mL vial. The reaction was heated at 40° C. for 3 days. The iodomethane was allowed to evaporate in the hood. The crude product was dissolved with 2 mL CH2Cl2 under reflux. The solution was precipitated into a mixture of acetone, ethyl acetate and hexane. The yellow solid was collected and dried in vacuo.

Workup

  1. additionwere added to a 20 mL vial
  2. customto evaporate in the hood
  3. dissolutionThe crude product was dissolved with 2 mL CH2Cl2
  4. temperatureunder reflux
  5. customThe solution was precipitated into a mixture of acetone, ethyl acetate and hexane
  6. customThe yellow solid was collected
  7. customdried in vacuo

Sources & evidence

ORD record
ord-590a8cee2b8c41b494ce41e5e9072916
Source dataset
uspto-grants-2014_12
Patent number
US08907105B1

Reaction notes

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