Methyl iodide → HCID 178439551, compound

HRID 1401376Notes

Reaction equation

HRID 1401376 reaction equation
[CH2:1]([C:4]1[N:5]=[N:6][N:7]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH:8]=1)[CH2:2][CH3:3].[CH3:15][I:16]>C(#N)C>[I-:16].[CH3:15][N+:5]1[C:4]([CH2:1][CH2:2][CH3:3])=[CH:8][N:7]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[N:6]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 1177228634-(4-propyl-1H-1,2,3-triazol-1-yl)pyridine

Product 1

HCID 178439551HCID 178439551, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-(4-propyl-1H-1,2,3-triazol-1-yl)pyridine (3.23 g, 17.15 mmol), methyl iodide (15 ml, 240 mmol), and acetonitrile (Volume: 20 ml) were added to a 100 mL round-bottom flask and refluxed for about 19 hours. The reaction was concentrated. The resulting solid was recrystallized from ethyl acetate (100 mL) and methanol (50 mL). The precipitate was filtered and dried in vacuo at 60° C. The following 3-methyl-4-propyl-1-(pyridin-4-yl)-1H-1,2,3-triazol-3-ium iodide structure was confirmed:

Workup

  1. temperaturerefluxed for about 19 hours
  2. concentrationThe reaction was concentrated
  3. customThe resulting solid was recrystallized from ethyl acetate (100 mL) and methanol (50 mL)
  4. filtrationThe precipitate was filtered
  5. customdried in vacuo at 60° C

Sources & evidence

ORD record
ord-089313338b4447009449c261939a94cf
Source dataset
uspto-grants-2014_12
Patent number
US08907105B1

Reaction notes

Loading…