8-(Benzyloxymethyl)-1,4-dioxaspiro[4.5]decane → Cyclohexanone, 4-[(phenylmethoxy)methyl]-

Participants

Reaction Steps

5.0 g (19.1 mmol) of 8-(benzyloxymethyl)-1,4-dioxaspiro[4,5]decane was dissolved in 150 ml of 1N aqueous hydrochloric acid solution, and the solution was stirred at room temperature for one hour. The reaction solution was washed twice with 100 ml of chloroform and neutralized with sodium carbonate. The neutralized solution was extracted twice with 100 ml of ethyl acetate and the organic layer was dried over sodium sulfate and concentrated under reduced pressure to obtain 4-(benzyloxymethyl)cyclohexanone (3.7 g, 89%) as a pale yellow oil.

Provenance & Evidence