Sodium Hydroxide → HCID 68304891, compound

HRID 1401760Notes

Reaction equation

HRID 1401760 reaction equation
Br.[CH3:2][C:3]1([CH3:23])[CH2:12][CH2:11][CH2:10][C:9]2[CH:8]=[C:7]([C:13]3[N:14]=[C:15]([CH:18]4[CH2:22][CH2:21][NH:20][CH2:19]4)[S:16][CH:17]=3)[CH:6]=[CH:5][C:4]1=2.C([O:27][CH2:28][CH2:29][CH2:30][CH2:31]Br)(=O)C.[OH-].[Na+]>CO>[CH3:2][C:3]1([CH3:23])[CH2:12][CH2:11][CH2:10][C:9]2[CH:8]=[C:7]([C:13]3[N:14]=[C:15]([CH:18]4[CH2:22][CH2:21][N:20]([CH2:31][CH2:30][CH2:29][CH2:28][OH:27])[CH2:19]4)[S:16][CH:17]=3)[CH:6]=[CH:5][C:4]1=2

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 784911-Butanol, 4-bromo-, 1-acetateHCID 68381040HCID 68381040, compound

Product 1

HCID 68304891HCID 68304891, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The preparation is carried out starting from 4-(5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2-pyrrolidin-3-ylthiazole hydrobromide and 4-bromobutyl acetate. The protecting group is cleaved off by means of a 1N NaOH solution in methanol. The product was purified by means of preparative HPLC and converted into the hydrochloride by treatment with methanolic HCl.

Workup

  1. customThe product was purified by means of preparative HPLC

Sources & evidence

ORD record
ord-d540349d23944c9db99df7eb4195470a
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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