3-((Tert-butyldimethylsilyl)oxy)propanal → 3-{1-[4-(1,1-Dimethylindan-5-yl)thiazol-2-yl]piperidin-4-ylamino}propan-1-ol

Participants

Reaction Steps

The preparation is carried out starting from 1-[4-(1,1-dimethylindan-5-yl)thiazol-2-yl]piperidin-4-ylamine hydrochloride and 3-(tert-butyldimethylsilanyloxy)propionaldehyde. The protecting group is cleaved off by means of a 1M tetramethylammonium/THF solution: The reaction mixture was stirred at room temperature overnight and subsequently evaporated to dryness. The product was purified by means of preparative HPLC and converted into the hydrochloride by treatment with methanolic HCl.

Provenance & Evidence