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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1401772Generated: November 1, 2026

3-((Tert-butyldimethylsilyl)oxy)propanal → HCID 67322952, compound

https://huagongshe.com/reaction/1401772

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-((Tert-butyldimethylsilyl)oxy)propanalHCID 3662392—
ReactantTBAF tetrahydrofuranHCID 11078149—
ReactantHCID 67323334HCID 67323334—
ProductHCID 67322952HCID 67322952—

Reaction Steps

The preparation is carried out starting from (S)-1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]pyrrolidin-3-ylamine and 3-(tertbutyldimethylsilanyloxy)propionaldehyde. The protecting group is cleaved off as already described by means of a 1M TBAF/THF solution. The product was purified by means of preparative HPLC and converted into the hydrochloride by treatment with methanolic HCl.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08907098B2
Source datasetuspto-grants-2014_12
ORD IDord-4f19eccf619048aaa888e3da37241c48
Source noteuspto-grants-2014_12