Glycidol → 3-{1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamino}propane-1,2-diol

Participants

Reaction Steps

150 mg (0.41 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine were dissolved in 2 ml of DMF, and 27.4 μl (0.41 mmol) of 2,3-epoxy-1-propanol were added. The reaction mixture was irradiated in the microwave at 120° C. for 3 h and subsequently stripped off to dryness. The residue was purified by means of flash chromatography on silica gel.

Provenance & Evidence