5-Hydroxypentanal → HCID 67323377, compound

HRID 1401777Notes

Reaction equation

Cl.[CH3:2][C:3]1([CH3:27])[CH2:12][CH2:11][C:10]([CH3:14])([CH3:13])[C:9]2[CH:8]=[C:7]([C:15]3[N:16]=[C:17]([N:20]4[CH2:25][CH2:24][CH:23]([NH2:26])[CH2:22][CH2:21]4)[S:18][CH:19]=3)[CH:6]=[CH:5][C:4]1=2.[OH:28][CH2:29][CH2:30][CH2:31][CH2:32][CH:33]=O>>[CH3:2][C:3]1([CH3:27])[CH2:12][CH2:11][C:10]([CH3:13])([CH3:14])[C:9]2[CH:8]=[C:7]([C:15]3[N:16]=[C:17]([N:20]4[CH2:25][CH2:24][CH:23]([NH:26][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][OH:28])[CH2:22][CH2:21]4)[S:18][CH:19]=3)[CH:6]=[CH:5][C:4]1=2

Participants

Reactant 2

HCID 202055-Hydroxypentanal

HCID 68381095HCID 68381095, compound

Product 1

HCID 67323377HCID 67323377, compound

Procedure

The preparation was carried out as already described via a reductive amination starting from 50 mg (0.08 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine hydrochloride and 8 mg (0.08 mmol) of 5-hydroxypentanal.

Sources & evidence

ORD record: ord-695090533f7c48e28a2db70016fc1d35
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08907098B2

Reaction notes

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