Tetrahydrofuran → HCID 68304050, compound

Participants

Reaction Steps

The preparation was carried out as already described starting from 100 mg (0.16 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine hydrochloride and 90 μl (0.32 mmol) of (6-bromohexyloxy)tert-butyldimethylsilane. The protecting group was cleaved off in THF using 7 equivalent of TMAF. The product was purified by means of preparative HPLC. The product is in the form of the hydrochloride.

Provenance & Evidence