HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67166643, compound → HCID 68380864, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67166643 | HCID 67166643 | — |
| Reactant | HCID 86671825 | HCID 86671825 | — |
| Product | HCID 68380864 | HCID 68380864 | — |
Reaction Steps
The preparation was carried out analogously starting from 50 mg (0.12 mmol) of 4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine hydrochloride and 30 mg (0.13 mmol) of (S)-2-(tert-butoxycarbonylmethylamino)-3-hydroxypropionic acid. The product was purified by means of flash chromatography on silica gel. The protecting group was cleaved off analogously using HCl in methanol. The product is in the form of the hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-06bd12276f554534802b40695db6377f |
| Source note | uspto-grants-2014_12 |