Water → HCID 67322718, compound

Participants

Reaction Steps

4.3 mg (0.11 mmol) of lithium aluminium hydride were initially introduced in 2 ml of THF, and 21 mg (0.04 mmol) of 2-{1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamino}pentanedioic acid diethyl ester from step a, pre-dissolved in 2 ml of THF, were slowly added. The reaction mixture was stirred at room temperature overnight, 20 ml of water were added, and the mixture was extracted twice with EA. The organic phase was dried over sodium sulfate, filtered, stripped off to dryness and purified by means of preparative HPLC. The product is in the form of the TFA salt.

Provenance & Evidence