Water → HCID 67324433, compound

Participants

Reaction Conditions

Reaction Steps

49 mg (0.10 mmol) of 2-({1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamino}methyl)cyclopropanecarboxylic acid ethyl ester from step a were dissolved in 2 ml of THF under nitrogen. 475 μl of a 1M diisobutylaluminium hydride solution in THF were added dropwise. The mixture was stirred at 60° C. overnight, water and EA were added, the mixture was filtered through Cellite, evaporated and purified by means of flash chromatography on silica gel.

Provenance & Evidence