Sodium Sulfate → HCID 53311621, compound

Participants

Reaction Steps

90 mg (0.171 mmol) of 3,3-dimethyl-4-oxo-5-{4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperazin-1-yl}pentanoic acid ethyl ester from step a was dissolved in 8 ml of THF. 1.71 ml (1.71 mmol) of a 1M lithium aluminium hydride solution in THF was added dropwise with ice-cooling. The mixture was stirred for a further 1 h with cooling, then stirred at room temperature and subsequently at 40° C. overnight, decomposed using a saturated sodium sulfate solution with cooling and extracted twice with EA. The organic phase was washed with a saturated sodium chloride solution, dried over sodium sulfate, filtered, evaporated to dryness and purified by means of preparative HPLC. The product is in the form of the hydrochloride.

Provenance & Evidence