Trifluoroacetate → HCID 67323964, compound

HRID 1401798Notes

Reaction equation

[CH3:1][C:2]1([CH3:33])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][CH:27]5[CH2:31][CH2:30][O:29][C:28]5=[O:32])[CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2.FC(F)(F)C([O-])=O>>[CH3:1][C:2]1([CH3:33])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][CH:27]([CH2:31][CH2:30][OH:29])[CH2:28][OH:32])[CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2

Participants

Reactant 2

HCID 84468Trifluoroacetate

HCID 67323215HCID 67323215, compound

Product 1

HCID 67323964HCID 67323964, compound

Procedure

The reduction was carried out analogously starting from 77 mg of 3-(2-{4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperazin-1-yl}-ethyl)dihydrofuran-2-one from step a. The product is in the form of the trifluoroacetate salt.

Sources & evidence

ORD record: ord-61f1cf822b98425e80b2b78d4aebc347
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08907098B2

Reaction notes

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