Hydrochloric Acid → HCID 68304026, compound

Participants

Reaction Steps

60 mg of 5-{4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperazin-1-yl}pentanoic acid ethyl ester from step a was dissolved in 2.5 ml of THF, 250 μl of water and 11 mg (0.43 mmol) of lithium hydroxide were added, and the mixture was stirred at room temperature overnight. The reaction mixture was neutralised using a 1N hydrochloric acid solution, evaporated to dryness and purified by means of preparative HPLC. The product is in the form of the trifluoroacetate salt.

Provenance & Evidence