Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Malonic acid, 3-chloropropyl-, diethyl ester | HCID 140413 | — |
| Reactant | HCID 53312286 | HCID 53312286 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 53311622 | HCID 53311622 | — |
Reaction Steps
200 mg (0.53 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperazine were dissolved in 5 ml of NMP, 235 μl (1.06 mmol) of 2-(3-chloropropyl)malonic acid diethyl ester and 220 μl (1.59 mmol) of triethylamine were added, and the mixture was stirred at 100° C. overnight. The reaction mixture was evaporated to dryness and purified by means of preparative HPLC. The product is in the form of the TFA salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08907098B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-8a3e153333d6409e8b3cf4b09f85f38c |
|---|
| Source note | uspto-grants-2014_12 |
|---|
