HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 53311711, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-((Tert-butyldimethylsilyl)oxy)acetaldehyde | HCID 4187788 | — |
| Reactant | HCID 67322590 | HCID 67322590 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 53311711 | HCID 53311711 | — |
Reaction Steps
The preparation was carried out as already described via a reductive amination starting from 50 mg (0.11 mmol) of 1-piperidin-4-yl-4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperazine and 24 mg (0.13 mmol) of (tertbutyldimethylsilanyloxy)acetaldehyde. The protecting group was cleaved off as already described using a 4N HCl solution in dioxane. The product is in the form of the hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-91f1b5f403334dc39572008a573dc92c |
| Source note | uspto-grants-2014_12 |