Sodium Sulfate → HCID 53312285, compound

Participants

Reaction Steps

1.15 g (2.51 mmol) of 4-{1-hydroxy-2-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)amino]ethyl}piperidine-1-carboxylic acid tert-butyl ester from step a was dissolved in 20 ml of DCM, and 15.61 ml (7.52 mmol) of Dess-Martin periodinane were added. The reaction mixture was stirred at room temperature for 30 min, 20 ml of a saturated sodium hydrogencarbonate solution and 5 ml of a saturated sodium sulfate solution were added, and the mixture was stirred vigorously for 30 min. The organic phase was separated off, and the water phase was extracted again with DCM. The organic phases were combined, dried, stripped off to dryness and purified by means of flash chromatography on silica gel.

Provenance & Evidence