Sodium Hydroxide → HCID 67323860, compound

HRID 1401826Notes

Reaction equation

HRID 1401826 reaction equation
Br.[CH3:2][CH:3]1[CH2:12][CH2:11][CH:10]([CH3:13])[C:9]2[CH:8]=[C:7]([C:14]3[N:15]=[C:16]([CH:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:6]=[CH:5][C:4]1=2.C([O:28][CH2:29][CH2:30][CH2:31][CH2:32]Br)(=O)C.[OH-].[Na+]>CO>[CH3:2][CH:3]1[CH2:12][CH2:11][CH:10]([CH3:13])[C:9]2[CH:8]=[C:7]([C:14]3[N:15]=[C:16]([CH:19]4[CH2:24][CH2:23][N:22]([CH2:32][CH2:31][CH2:30][CH2:29][OH:28])[CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:6]=[CH:5][C:4]1=2

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 784911-Butanol, 4-bromo-, 1-acetateHCID 68380594HCID 68380594, compound

Product 1

HCID 67323860HCID 67323860, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The preparation was carried out as already described starting from 150 mg (0.37 mmol) of 4-[4-(5,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]-piperidine hydrobromide and 109 μl (0.74 mmol) of 4-bromobutyl acetate. The protecting group was cleaved off by means of a 1N sodium hydroxide solution in methanol. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.

Workup

  1. customThe product was purified by means of preparative HPLC

Sources & evidence

ORD record
ord-b3f4204fedbc4933b20f798afdd89f41
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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