Water → HCID 67324298, compound

Participants

Reaction Steps

3.5 g (6.90 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine-4-carboxylic acid ethyl ester hydrobromide from step a were slurried in 25 ml of THF, 21 ml of water and 843 mg (34.48 mmol) of lithium hydroxide were added, and the mixture was stirred at room temperature overnight. The reaction mixture was evaporated in a rotary evaporator, adjusted to pH=1 using a 1N hydrochloric acid solution and then extracted twice with EA. The combined organic phases were dried over sodium sulfate, filtered and evaporated.

Provenance & Evidence