2-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one → 4-((2-Hydroxyethyl)-{1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-yl}amino)butan-1-ol

関与物質

反応手順

The preparation was carried out as already described starting from 800 mg (1.01 mmol) of 2-bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone and 452 mg (1.01 mmol) of 4-[(4-hydroxybutyl)-(2-hydroxyethyl)amino]-piperidine-1-carbothioic acid amide from step d. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.

情報源と証拠