HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-{1-[4-(5,5-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-thiazol-2-yl]piperidin-4-ylamino}ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-((Tert-butyldimethylsilyl)oxy)acetaldehyde | HCID 4187788 | — |
| Reactant | 1-[4-(5,5-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine hydrochloride | HCID 68380708 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-{1-[4-(5,5-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-thiazol-2-yl]piperidin-4-ylamino}ethanol | HCID 67323364 | — |
Reaction Steps
The preparation is carried out as described starting from 60 mg (0.16 mmol) of 1-[4-(5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine hydrochloride and 34 μl (0.16 mmol) of (tert-butyldimethylsilanyloxy)acetaldehyde. The protecting group is cleaved off using a 4N HCl solution in dioxane. The purification is carried out by means of preparative HPLC. The product is in the form of the formate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-b87204c1c7774a9180dea2431445911b |
| Source note | uspto-grants-2014_12 |