HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-{4-[4-(5,6,7,8-Tetrahydronaphthalen-2-yl)thiazol-2-yl]-piperidin-1-yl}butan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Butanol, 4-bromo-, 1-acetate | HCID 78491 | — |
| Reactant | 4-[4-(5,6,7,8-Tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine | HCID 24261840 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-{4-[4-(5,6,7,8-Tetrahydronaphthalen-2-yl)thiazol-2-yl]-piperidin-1-yl}butan-1-ol | HCID 67323637 | — |
Reaction Steps
The preparation is carried out as described starting from 39 mg (0.13 mmol) of 4-[4-(5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine and 30 μl (0.20 mmol) of 4-bromobutyl acetate. The protecting group is cleaved off by means of a 2N NaOH solution in methanol. The product is in the form of the hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-79add1046d1a47a5b433fcd251cacd67 |
| Source note | uspto-grants-2014_12 |