HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4,5,5-Tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane → 1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4,5,5-Tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane | HCID 11243929 | — |
| Reactant | HCID 67323440 | HCID 67323440 | — |
| Product | 1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-one | HCID 67322575 | — |
Reaction Steps
The preparation is carried out as already described via a Suzuki reaction starting from 339 mg (1.18 mmol) of 1-(4-bromothiazol-2-yl)piperidin-4-one (preparation already described above) and 449 mg (1.30 mmol) of 4,4,5,5-tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-48fa92717509459db33f6ac68cd32e6d |
| Source note | uspto-grants-2014_12 |