Hydrochloric Acid → (S)-4-{1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamino}butane-1,2-diol

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	(2S)-4-aminobutane-1,2-diol	HCID 55281176	—
Reactant	1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-one	HCID 67322575	—
Product	(S)-4-{1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamino}butane-1,2-diol	HCID 68381133	—

Reaction Steps

The preparation is carried out analogously starting from 22 mg (0.21 mmol) of (S)-4-aminobutane-1,2-diol and 80 mg (0.21 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-one. The product is in the form of the hydrochloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08907098B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-121963b2d2a04c25966f08943c863245
Source note	uspto-grants-2014_12