HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3aS,4R,7aR)-2,2-dimethylhexahydro-1,3-benzodioxol-4-amine → ((3aS,4R,7aR)-2,2-dimethylhexahydrobenzo-1,3-dioxol-4-yl)-{1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]-piperidin-4-yl}amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3aS,4R,7aR)-2,2-dimethylhexahydro-1,3-benzodioxol-4-amine | HCID 58369647 | — |
| Reactant | 1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-one | HCID 67322575 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | ((3aS,4R,7aR)-2,2-dimethylhexahydrobenzo-1,3-dioxol-4-yl)-{1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]-piperidin-4-yl}amine | HCID 67323175 | — |
Reaction Steps
The preparation is carried out analogously in THF starting from 27 mg (0.16 mmol) of (3aS,4R,7aR)-2,2-dimethylhexahydrobenzo-1,3-dioxol-4-ylamine and 60 mg (0.16 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-one. The purification is carried out by means of flash chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-ad8674b999f24b9db3b136dc718b9884 |
| Source note | uspto-grants-2014_12 |